Here’s what consumers have asked with answers from Proactiv staff and previous consumers.
The FDA has stated that Benzoyl Peroxide, the main Proactive ingredient, is generally safe for use (GRASE) They also follow all of the FDA rules and regulations regarding over the counter products.
My daughter used it for a few months and it just didn't work for her. However, it didn't cause any side effects either.
I think the products probably work best if you use the cleanser, toner and cream.